Macy's is one of the most well known stores of all time, and their website reflects upon their rich and long history well. The Macy's website is fairly no frills, but is mostly easy to shop at. They have one of the biggest selections out there, making it easy to find what you are looking for.
Macy's is almost always having some kind of sale. I have bought clothing and home products for prices lower than I could find anywhere else. I have frequently gone to Macys.com ready to pay full price for something only to find it available for 75% less than retail price.
Their shipping is fast and free above certain dollar thresholds which change often. There are always promo codes available too.